Job Title: QC Technologist - Global Biopharmaceutical

Contract: 12 months

Location: Cambridge

Salary: £15.80

Hours: 37.5 hours per week

This is a great opportunity for a graduate in a biochemistry related degree looking for their first role in the industry. 0-2 years industry experience is required for this role.

This role is for The Cell Engineering group, based in Cambridge UK, it is a pivotal member of Mammalian Expression System Centre, focused on improving host cell line functionality through cutting edge science and technology innovations. As a Technologist - Cell Engineering you will support the delivery of R&D projects.

Key Responsibilities will include:

• Contribute to the delivery of new mammalian expression hosts and vector systems for the expression of complex therapeutic proteins.
• Engineer mammalian cell lines (e.g. random integration, targeted integration and gene editing - e.g. CRISPR-based systems).
• Generate mammalian expression vectors using state of the art assembly techniques.
• Phenotypic characterisation of edited cell lines with relevant assays (e.g. NGS, ddPCR, qPCR and flow cytometry) and cell culture techniques (e.g., shake flask/ bioreactor).
• Collate, analyse, evaluate and sign-off data to produce good quality information and traceable records under the direction of the project lead.
• Presentation of results in written and oral reports.
• Work closely with other groups within R&D to deliver solutions or improvements in recombinant protein expression (in particular with R&D Process Development, Microbial Expression & Protein Analytics)
• Actively keep abreast of relevant academic literature (e.g., in the field of cell engineering and expression technologies).

Candidate Requirements:

• BSc/MSc Degree in Life Sciences / Science/ Molecular Biology
• Practical experience within in an industrial/academic setting is desirable.
• Good technical background in molecular biology (electrophoresis, PCR, vector construction) and cell culture (preferably mammalian cells) with the aim of developing or manipulating mammalian expression systems.
• Clear demonstration of strong technical skills, scientific execution and data analysis.
• A proactive attitude to working and solving challenging problems.
• Good working knowledge of statistics and expertise in design of
• Experience of cell line engineering, ideally with CRISPR-based systems would be an advantage and highly desirable.
• Good understanding of synthetic biology technologies would be desirable.

Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy.